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The addition of exogenous melatonin improves the intestinal microbial composition and circadian rhythm in high-fat diet-fed mice, thereby regulating the hosts metabolic circadian clock and lipid metabolism [57]

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The practical version: cut your usual amount, drink water alongside it, and dont test it for the first time on the same day as a dose increase

Keeping meals small and bland for the first day after injection, then gradually returning to normal eating by day two or three